Parkinson’s disease is a neurological disorder for which the symptoms worsen overtime, making its treatment difficult. An early detection of Parkinson’s disease can help patients get effective treatment before the disease becomes severe. This paper focuses on applying and evaluating different machine learning techniques to predict Parkinson’s disease based on patient’s voice data. The various algorithms in MATLAB were used to train models, and the better performing models among them were chosen. The chosen algorithms were logistic regression, SVM (linear and quadratic), and weighted KNN. The quadratic SVM classifier performed best among other classifiers to predict Parkinson’s disease. The findings of this study could contribute to the development of better diagnostic tools for early prediction of Parkinson’s disease. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.